monocyte expression of toll-like receptor-4 in patients with stable angina undergoing percutanoeus coronary intervention
نویسندگان
چکیده
background: toll like receptors (tlrs) are well recognized players in inflammatory conditions. among them tlr-4 is involved in chronic inflammatory processes such as formation of atherosclerotic plaques. objective: the present study was aimed to examine the effects of percutanoeus coronary intervention (pci) as a revascularization method on monocyte expression of htlr-4 and on the serum levels of two proinflammatory cytokines (tnf-α and il-1β). methods: blood samples were obtained from 41 patients with stable angina who were candidates for pci. the samples were collected immediately before and 2h and 4h after pci. the expression of htlr-4 on cd14+ monocytes and the serum levels of tnf-α and il-1β were measured using flowcytometry and elisa techniques, respectively. results: by comparing the frequency of circulating htlr-4+/cd14+ monocytes at different time points, it was observed that pci procedure up regulates the monocyte expression of htlr-4 (p
منابع مشابه
Monocyte Expression of Toll-like Receptor-4 in Patients with Stable Angina Undergoing Percutanoeus Coronary Intervention
Background: Toll like receptors (TLRs) are well recognized players in inflammatory conditions. Among them TLR-4 is involved in chronic inflammatory processes such as formation of atherosclerotic plaques. Objective: The present study was aimed to examine the effects of percutanoeus coronary intervention (PCI) as a revascularization method on monocyte expression of hTLR-4 and on the serum levels ...
متن کاملHydrocortisone Reduces Toll-Like Receptor 4 Expression on Peripheral CD14+ Monocytes in Patients Undergoing Percutanoues Coronary Intervention
Bacground: Evidence from several lines of investigations suggests that Toll-like receptor 4 (TLR4) is involved in atherosclerosis as a bridge between innate and acquired immunity. Percutaneous coronary intervention (PCI) can trigger inflammation through activation of human TLR4 (hTLR4) on monocytes. Hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of a...
متن کاملhydrocortisone reduces toll-like receptor 4 expression on peripheral cd14+ monocytes in patients undergoing percutanoues coronary intervention
bacground: evidence from several lines of investigations suggests that toll-like receptor 4 (tlr4) is involved in atherosclerosis as a bridge between innate and acquired immunity. percutaneous coronary intervention (pci) can trigger inflammation through activation of human tlr4 (htlr4) on monocytes. hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of a...
متن کاملToll Like Receptor 2 and 4 Expression in Peripheral Blood Mononuclear Cells of Multiple Sclerosis Patients
Background: Multiple sclerosis (MS) is a T cell mediated autoimmune disease with unknown etiology. Appropriate MS therapeutic strategies need thorough understanding of both disease etiology and pathogenesis mechanisms. Ligation of TLR-2 and TLR-4 stimulates the production of several cytokines leading to CNS autoimmunity and neurodegenerative diseases. Objective: To find a relationship between M...
متن کاملHydrocortisone reduces Toll-like receptor 4 expression on peripheral CD14+ monocytes in patients undergoing percutaneous coronary intervention.
BACKGROUND Evidence from several lines of investigations suggests that Toll-like receptor 4 (TLR4) is involved in atherosclerosis as a bridge between innate and acquired immunity. Percutaneous coronary intervention (PCI) can trigger inflammation through activation of human TLR4 (hTLR4) on monocytes. Hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of a...
متن کاملtoll like receptor 2 and 4 expression in peripheral blood mononuclear cells of multiple sclerosis patients
background: multiple sclerosis (ms) is a t cell mediated autoimmune disease with unknown etiology. appropriate ms therapeutic strategies need thorough understanding of both disease etiology and pathogenesis mechanisms. ligation of tlr-2 and tlr-4 stimulates the production of several cytokines leading to cns autoimmunity and neurodegenerative diseases. objective: to find a relationship between m...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of immunologyجلد ۹، شماره ۳، صفحات ۱۴۹-۱۵۸
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023